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How does room ventilation affect airborne disease transmission in a health care facility? This monograph addresses the topic through a review of the literature. Noting that the majority of studies conducted on ventilation and disease transmission have been observational or animal studies not applicable to human disease, Farhad Memarzadeh, PhD, PE, examines research findings that consider the effects of air changes per hour (ACH) on airborne infection transmission. Current recommended ventilation rates are not always based on hard data, but on experience. The monograph looks at research on hospitals, schools, aircraft, and other vehicles.